Fluorescence Microscopy

Fluorescence multi-color whole slide images can be achieved simply by adding the fluorescence option to the NanoZoomer XR, 2.0-HT and 2.0-RS family. Scanned whole slide images allow you to review and analyze without fear of sample degradation.

Challenges in Biomarker and Brain Research

  • Imaging of entire tissues at high resolution
  • Imaging of multiple labels
  • Imaging of multiple tissue slides for 3D imaging
  • Image analysis of a high number of slides

Our solutions

  • The NanoZoomer, equipped with the multi-colour fluorescence module can auto- or semi-automatically scan entire tissue sections of multiple slides
  • Brightfield focusing can be used to avoid photo-bleaching during the focusing process and provides superb image quality over large tissue sections
  • IUsing Hamamatsu NDP.analyze or a third party software, scanned slide data are quickly ready for analysis on local computers or via a network.

References

  • Pommerencke T, Westphal K, Ernst C, Safferling K, Dickhaus H, Steinberg T, Tomakidi P, Grabe N. Spatial quantification and classification of skin response following perturbation using organotypic skin cultures. Bioinformatics. 2010 Nov 1;26(21):2760-6.
  • Hashiguchi A, Hashimoto Y, Suzuki H, Sakamoto M. Using immunofluorescent digital slide technology to quantify protein expression in archival paraffin-embedded tissue sections. Pathol Int. 2010 Nov;60(11):720-5
  • Discenza CB, Reinagel P. Dorsal lateral geniculate substructure in the long-evans rat: a cholera toxin B subunit study. Front Neuroanat. 2012;6:40. doi: 10.3389/fnana.2012.00040. Epub 2012 Sep 25.
  • Gaucher D, Arnault E, Husson Z, Froger N, Dubus E, Gondouin P, DherbĂ©court D, Degardin J, Simonutti M, Fouquet S, Benahmed MA, Elbayed K, Namer IJ, Massin P, Sahel JA, Picaud S. Taurine deficiency damages retinal neurones: cone photoreceptors and retinal ganglion cells. Amino Acids. 2012 Nov;43(5):1979-93.
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